CAS 76144-81-5

1 kg /bag and 25 kg /drum ----------Mildronate

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Specification of  Mildronate

More About Mildronate

Product Name: Mildronate

CAS: 76144-81-5

MF: C6H14N2O2
MW: 146.18756

Appearance : white crystalline powder 

Purity :99% min 

Use Of  Mildronate

1, Meldronate can improve energy metabolism of myocardial cells, carnitine-dependent inhibition of fatty acid oxidation, enhance intracellular glucose metabolism to provide energy to the tissue through anaerobic glycolysis, improve myocardial ischemia, hypoxia symptoms, with other drugs (such as vasodilators, diuretics, etc.) combined for the treatment of ischemic heart disease.
2, Meldronate promotes redistribution of blood in the heart and brain ischemic area for a variety of acute and chronic treatment of cerebral circulation disorders.
3, the drug by improving fat metabolism, can improve people's ability to work, relieve mental and physical over-stress syndrome, athletes taking the drug may improve athletic performance during training and competition.
4, to eliminate chronic alcoholism during abstinence syndrome patients with seizure of their nervous system and damage, in addition to the drug may also improve due to nutritional disorders caused by retinal vascular lesions.
5, membrane protective effect: when the effort causing ischemic myocardial cell stress response, the inner mitochondrial fatty acid decomposition increased cell fatty acid metabolite accumulation, means the destruction of the cell membrane, increase intracellular Ca
6, the energy optimization of the role: Meldonium can reduce the accumulation of long chain acyl carnitine, carnitine-dependent fatty acid oxidation can be suppressed, so that the fatty acid oxidation to glucose oxidation more favorable anoxic myocardial energy metabolism, namely promote anaerobic glycolytic pathway of oxidation, so this product has anti-anoxia utility and cardioprotective activity.
7, effects on energy metabolism enzymes: Meldonium isoproterenol-induced strengthening can prevent blood lactate dehydrogenase (cardiac-specific isozyme) liver different life, to prevent the increase in the activity of creatine phosphokinase.
8, on the excretion of carnitine: Another study shows that Meldonium competitive inhibition in vivo in addition to butyric acid betaine-hydroxylase, blocking the biosynthesis of carnitine, but also the competitive impact of carnitine reabsorption in the kidney.
9, for the protection of the ischemic heart: myocardial ischemic area, left anterior descending artery occlusion not only reduces the tissue levels of ATP, ADP and creatine phosphate, also increased tissue levels of AMP and lactate, reduce energy charge potential the value of. The results in Table Mingmi β- oxidation of fatty acids and thus inhibits flexor hydrazine ischemic myocardium energy metabolism is very favorable 

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